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Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma
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Abstract
Background/Aims: Mean platelet volume (MPV) reflects platelet activation. Platelets have an important role in tumor progression and metastasis. In this study, we wanted to investigate the effect of MPV on survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC).
Materials and Methods: All data of 376 patients who underwent LT and pathologically diagnosed with HCC were analyzed. By determining the cut-off of MPV (10.2 fL), 2 groups with high and low MPV were formed. The groups were compared within themselves. Factors affecting survival were determined by univariate and multivariate analysis.
Results: When the groups were compared, patients with low MPV had significantly higher platelet counts, larger tumor sizes, lower BMI, and higher recurrence rates. In multivariate analysis, GGT >104, AFP >200 μg/L, largest tumor diameter >5 cm, and lower MPV were found to be independent risk factors that affected the prognosis. Tumor-free survival was significantly worse in the lower MPV group (P = .002).
Conclusion: Pre-transplant low MPV may be useful in predicting poor prognosis and a high rate of tumor recurrence in patients with HCC after liver transplantation.
Cite this article as: Şentürk M, İnce V, Üreyen O, et al. Mean platelet volume is a poor prognostic factor in patients undergoing liver transplantation for hepatocellular carcinoma. Turk J Gastroenterol. 2025;36(3):169-173.
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References
1. Globobcan. Liver [Internet]. Geneva: World Health Organisation International Agency for Research on Cancer; 2020;p. 1-2. Available at: https://gco.iarc.fr/today/data/factsheets/cancers/11-Liver-factsheet.pdf.
2. Ince V, Akbulut S, Otan E, et al. Liver transplantation for hepatocellular carcinoma: Malatya experience and proposals for expanded criteria. J Gastrointest Cancer. 2020;51(3):998-1005. [CrossRef]
3. Degroote H, Geerts A, Verhelst X, Van Vlierberghe H. Different models to predict the risk of recurrent hepatocellular carcinoma in the setting of liver transplantation. Cancers. 2022;14(12):2973. [CrossRef]
4. Zhang AB, Zhang ZH, Zhang J, et al. Lower mean platelet volume is a risk indicator of hepatocellular carcinoma recurrence following liver transplantation. Hepatobiliary Pancreat Dis Int. 2019;18(3):223-227. [CrossRef]
5. Yin J-B, Niu Y, Qian L-Y, Zhang X, Liu Z-P, Wang R-T. Mean platelet volume predicts survival in patients with hepatocellular carcinoma and type 2 diabetes. Diabetes Res Clin Pract. 2019;151:120-127. [CrossRef]
6. Liu XH, Yang W, Li C, et al. Nomogram for predicting overall survival in stage II-III colorectal cancer. Cancer Med. 2020;7:2363-2371.
7. Tanriverdi O, Menekse S, Teker F, et al. The mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: a retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG). J BUON. 2016;21(4):840-850.
8. An S, Eo W, Han GY, Park S, Lee S. Preoperative mean platelet volume is a prognostic biomarker for survival in patients with gastric cancer: a cohort study. Medicine (Baltimore). 2022;101(36):e30504. [CrossRef]
9. Kumagai S, Tokuno J, Ueda Y, et al. Prognostic significance of preoperative mean platelet volume in resected non-small-cell lung cancer. Mol Clin Oncol. 2015;3(1):197-201. [CrossRef]
10. Ince V, Carr BI, Bag HG, et al. Liver transplant for large hepatocellular carcinoma in Malatya: the role of gamma glutamyl transferase and alpha-fetoprotein, a retrospective cohort study. World J Gastrointest Surg. 2020;12(12):520-533. [CrossRef]
11. Zuo X, Kong W, Feng L, Zhang H, Meng X, Chen W. Elevated platelet distribution width predicts poor prognosis in hepatocellular carcinoma. Cancer Biomark. 2019;24(3):307-313. [CrossRef]
12. Geranpayehvaghei M, Dabirmanesh B, Khaledi M, et al. Cancer-associated-platelet-inspired nanomedicines for cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021;13(5):e1702. [CrossRef]
13. Kanikarla Marie P, Fowlkes NW, Afshar-Kharghan V, et al. The provocative roles of platelets in liver disease and cancer. Front Oncol. 2021;11:643815. [CrossRef]
14. Omar M, Tanriverdi O, Cokmert S, et al. Role of increased mean platelet volume (MPV) and decreased MPV/platelet count ratio as poor prognostic factors in lung cancer. Clin Respir J. 2018;12(3):922-929. [CrossRef]
15. Chang J, Lin G, Ye M, et al. Decreased mean platelet volume predicts poor prognosis in metastatic colorectal cancer patients treated with first-line chemotherapy: results from mCRC biomarker study. BMC Cancer. 2019;19(1):15. [CrossRef]
16. Zhou S, Ma Y, Shi Y, et al. Mean platelet volume predicts prognosis in patients with diffuse large B-cell lymphoma. Hematol Oncol. 2018;36(1):104-109. [CrossRef]
17. Chu T, Hu S, Qi J, et al. Bifunctional effect of the inflammatory cytokine tumor necrosis factor alpha on megakaryopoiesis and platelet production. J Thromb Haemost. 2022;20(12):2998-3010. [CrossRef]
18. Taşkaldiran I, Omma T, Önder ÇE, et al. Neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in different etiological causes of thyrotoxicosis. Turk J Med Sci. 2019;49(6):1687-1692. [CrossRef]
19. Ludhiadch A, Yadav P, Singh SK, et al. Evaluation of mean platelet volume and platelet count in ischemic stroke and its subtypes: focus on degree of disability and thrombus formation. Int J Neurosci. 2022:1–8.
20. Misra DP, Rathore U, Patro P, Agarwal V, Sharma A. Corticosteroid monotherapy for the management of Takayasu arteritis—a systematic review and meta-analysis. Rheumatol Int. 2021;41(10):1729-1742. [CrossRef]
21. Scheiner B, Kirstein M, Popp S, et al. Association of platelet count and mean platelet volume with overall survival in patients with cirrhosis and unresectable hepatocellular carcinoma. Liver Cancer. 2019;8(3):203-217. [CrossRef]