Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population
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Abstract
Background and Aims: Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-γ and IFN-γR1 genes may influence the susceptibility to HBV. Here, we evaluated the impact of interferon gamma <em>(+874 T/A</em>) and its receptor<em> (-611A/G, +189G</em><em><span>/</span></em><em>C</em> and <em>+95C/T</em>) polymorphisms and the risk of HBV in Iranian patients.
Materials and Methods<em>:</em> SNPs of interferon gamma and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using ARMS-PCR and PCR- RFLP method.
Results: In this study, we showed an obvious relationship between <em>IFN-γ SNPs</em> and susceptibility to chronic HBV. Our findings suggest that <em>IFN-γ-874A</em> allele increases the risk of disease and carriers of the T allele have reduced susceptibility to infection. In addition, there was not any relationship between the <em>-611A/G, +189G</em><em><span>/</span></em><em>C </em>and<em> +95C/T</em> regions of IFN-γ R1 and HBV.
Conclusions: Our observations demonstrate <em>+874 T/A</em> SNP as a predicting factor in patients who have the risk of HBV.
Cite this article as: Heidari Z, Moudi B, Mahmoudzadeh-Sagheb H. Interferon gamma gene polymorphisms and chronic hepatitis B infections in Iranian population. Turk J Gastroenterol 2020; 31(7): 515-21.
Materials and Methods<em>:</em> SNPs of interferon gamma and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using ARMS-PCR and PCR- RFLP method.
Results: In this study, we showed an obvious relationship between <em>IFN-γ SNPs</em> and susceptibility to chronic HBV. Our findings suggest that <em>IFN-γ-874A</em> allele increases the risk of disease and carriers of the T allele have reduced susceptibility to infection. In addition, there was not any relationship between the <em>-611A/G, +189G</em><em><span>/</span></em><em>C </em>and<em> +95C/T</em> regions of IFN-γ R1 and HBV.
Conclusions: Our observations demonstrate <em>+874 T/A</em> SNP as a predicting factor in patients who have the risk of HBV.
Cite this article as: Heidari Z, Moudi B, Mahmoudzadeh-Sagheb H. Interferon gamma gene polymorphisms and chronic hepatitis B infections in Iranian population. Turk J Gastroenterol 2020; 31(7): 515-21.