Pancreatobiliary - Original Article
Vol. 30 No. 10 (2019): 2019.30.10-Turkish Journal of Gastroenterology
Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis
Main Article Content
Abstract
Background/Aims: The aim of this study was to compare the dynamic thiol/disulfide (SS) homeostasis and ischemia-modified albumin (IMA) concentration between healthy subjects and patients with mild acute pancreatitis (AP).<br>
Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.<br>
Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.<br>
Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.
Cite this article as: Uyanıkoğlu A, Sabuncu T, Yıldız R, Cindoğlu Ç, Kirmit A, Erel Ö. Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turk J Gastroenterol 2019; 30(10): 899-902.
Materials and Methods: A total of 28 patients with AP (AP group) and 35 age- and sex-matched healthy individuals (control group) were included in this study. Serum thiols/SS and IMA concentrations were measured and compared between the two groups.<br>
Results: The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower in the AP group than in the control group (224.7±80.3 μmol/L vs. 314.66±87.5 μmol/L, p<0.001 and 273.3±76.8 vs. 346.9±79 μmol/L, p<0.001, respectively). SS levels were significantly higher in the AP group than in the control group (24.2±11.1 μmol/L vs. 16.1±9.9 μmol/L, p<0.054). There were no differences in the IMA concentration and the mean IMA/albumin ratio (IMAR) between both the groups.<br>
Conclusion: We found that mild AP may affect serum thiol and SS levels, and cause impaired thiol/SS homeostasis.
Cite this article as: Uyanıkoğlu A, Sabuncu T, Yıldız R, Cindoğlu Ç, Kirmit A, Erel Ö. Impaired thiol/disulfide homeostasis in patients with mild acute pancreatitis. Turk J Gastroenterol 2019; 30(10): 899-902.